No disease is pleasant. But if I had to pick the “worst of the worst” I would have to choose Alzheimer's. I watched my mother go downhill first hand. Every time I thought, “It can’t get worse” it indeed would. It started with simple absent mindedness when I was 9 or 10 years old. Progressed to alarming forgetfullness when I was in high school. I left home at 19 never to return after a brutal argument.